The Siderovski Laboratory is located at West Virginia University (Morgantown, WV). On July 1st, 2012, Dr. Siderovski accepted a position as E.J. Van Liere Endowed Professor and Chair of the WVU Department of Physiology and Pharmacology.
The long-standing research focus of the Siderovski lab has been in the field of regulators of heterotrimeric G protein signaling, having discovered the G-alpha GAP superfamily (“RGS proteins”) in 1996 based on T-lymphocyte activation as well as yeast complementation studies. In 1999, Dr. Siderovski also discovered the GoLoco motif protein family of G-alpha·GDP dissociation inhibitors based on bioinformatic analyses. These discoveries led to Dr. Siderovski being awarded the prestigious John J. Abel Award from the American Society for Pharmacology and Experimental Therapeutics as the outstanding American pharmacologist under 40 in 2004. Since these initial discoveries, his research into the function of novel regulators in G protein signal transduction has led to over 130 high-profile papers, reviews, and book chapters on the topic. As a complement to this basic science focus on G protein regulators, Dr. Siderovski also has both industrial and academic experience in high-throughput screening and small molecule discovery programs, beginning with a multi-year stint in the 1990’s at the AMGEN Institute (Toronto, Canada) responsible for leveraging basic research discoveries into new drug discovery projects at Amgen Inc. These early industrial efforts have resulted in three issued patents. Presently at the West Virginia School of Medicine, Dr. Siderovski is the E.J Van Liere Endowed Professor and Chair of the Department of Physiology and Pharmacology, being specifically charged with reinvigorating WVU’s pharmacology and toxicology scholarship towards clinical and translational research foci.